相关实验视频
Updated: May 6, 2026

09:11
A Mouse Model of in Utero Transplantation
Published on: January 28, 2011
18.9K
子的传播和体内毒性发生在两个不同的机械阶段
Malin K Sandberg1, Huda Al-Doujaily, Bernadette Sharps
1MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Nature
|February 26, 2011
概括
哺乳动物的子会导致致命的神经退行性疾病. 这项研究揭示了子传播发生在两个阶段,第二阶段确定临床发病和解开毒性和毒性的感染性.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 传染性疾病 传染性疾病
背景情况:
- 哺乳动物的子会导致致命的神经退行性疾病,如克鲁茨菲尔特-雅各布病.
- 性疾病表现出长时间的潜伏期,随后是快速的临床衰退.
- 人们对子传播,神经毒性和疾病发病之间的联系知之甚少.
研究的目的:
- 阐明子传播,神经毒性物种生成和临床发病之间的关系.
- 为了研究大脑中子传播的阶段.
- 确定细胞质蛋白度在疾病进展中的作用.
主要方法:
- 在实验动物模型中研究了子传播.
- 分析了子标位和随时间的疾病进展.
- 与潜伏期和疾病阶段相关的蛋白表达水平.
主要成果:
- 子传播发生在两个不同的阶段:最初的指数阶段达到最大的子位数,然后是平原阶段.
- 平原阶段,而不是最初的传播,决定了临床发病的时间.
- 子的潜伏期与平原阶段的细胞质蛋白度成反比例.
结论:
- 子的传染性和神经毒性是不结合的;子本身不是直接的神经毒性.
- 子催化细胞子蛋白 (PrP(C)) 的神经毒性物种的形成.
- 神经毒性产生时,子传播和,切换到一个不同的有毒路径.
相关概念视频
In-vitro Mutagenesis
14.8K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
14.8K
Viral Recombination
22.3K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
22.3K
Types of Genetic Transfer Between Organisms
24.8K
Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
24.8K
Infection
11.7K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.7K

