不稳定的胸痛. 血小板行为和预后在渐进性心痛和中级冠状动脉综合征
P Grande1, A M Grauholt, J K Madsen
1Medical Department B (Cardiology), Rigshospitalet, University Hospital, Copenhagen, Denmark.
Circulation
|January 1, 1990
概括
患有中级冠状动脉综合征的患者表现出血小板过度聚集和血小板 B2 的升高,表明血小板行为发生了变化. 这与渐进性胸痛患者形成鲜明对比,表明不稳定的胸痛有不同的病理生理机制.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 血栓形成的原因是血栓形成.
背景情况:
- 不稳定的心痛包括中等冠状动脉综合征 (休息疼痛,ST抑郁症) 和渐进性心痛等疾病.
- 血小板激活在急性冠状动脉综合征的病理生理学中起着至关重要的作用.
- 了解不同不稳定性胸痛子组的不同血小板行为对于预后和治疗至关重要.
研究的目的:
- 为了比较中等冠状动脉综合征患者的血小板聚合和激活标志物与渐进性心痛.
- 评估血小板行为与健康对照的关系.
主要方法:
- 活体血小板聚合试验使用阿拉基酸.
- 测量血清血红素B2,血β血红蛋白和血小板因子的测量 4.
- 在13名中期冠状动脉综合征患者,14名慢性心痛患者和20名健康对照患者之间进行了比较.
主要成果:
- 与对照组相比,两个不稳定的心痛组都显示出血小板过度聚集 (p < 0.01).
- 中级冠状动脉综合征患者的血清血红素B2,血β血红球蛋白和血小板因子4显著增加 (p < 0.01).
- 与对照组相比,渐进性胸痛患者的这些标志物水平没有显著不同.
结论:
- 患有中级冠状动脉综合征的患者表现出严重改变的血小板行为,其特征是过度聚合和激活标志物的增加.
- 在中级冠状动脉综合征中,这些血小板变化与在渐进性心痛中观察到的不同.
- 中级冠状动脉综合征中血小板行为的改变可能与冠状动脉血栓的更高频率和更差的预后相关.
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