大发HCII类交换激活器CIITA是淋巴细胞癌中经常出现的基因融合合作伙伴

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Christian Steidl1, Sohrab P Shah, Bruce W Woolcock

  • 1Department of Pathology and Laboratory Medicine, Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics, Vancouver, British Columbia, V5Z4E6, Canada.

Nature
|March 4, 2011
PubMed
概括

在霍奇金淋巴瘤和原发性中间体B细胞淋巴瘤中发现了涉及CIITA基因的复发性基因融合. 这些CIITA变化影响瘤-免疫相互作用和患者的存活率,这表明淋巴状癌症中存在一种新的机制.

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