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Visualization of DNA Repair Proteins Interaction by Immunofluorescence
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HDACs与DNA损伤反应,双链断裂的处理和自有关

Thomas Robert1, Fabio Vanoli1, Irene Chiolo1,2

  • 1Fondazione IFOM (Istituto FIRC di Oncologia Molecolare), IFOM-IEO Campus, via Adamello 16, Milan 20139, Italy.

Nature
|March 4, 2011
PubMed
概括

激素脱乙酶 (HDAC) 抑制会破坏酵母中的DNA损伤反应途径,影响Mec1 (ATR) 激活和DNA修复. 这一过程涉及Sae2通过自的乙化和降解,影响染色体的稳定性.

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