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SCF(FBW7) 通过向MCL1进行无处不在和破坏来调节细胞亡

Hiroyuki Inuzuka1, Shavali Shaik, Ichiro Onoyama

  • 1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.

Nature
|March 4, 2011
PubMed
概括

在T细胞急性淋巴细胞白血病 (T-ALL) 中,瘤抑制剂FBW7的丧失导致MCL1的过度表达,促进细胞存活. 恢复FBW7或消耗MCL1会使T-ALL细胞对向治疗重新敏感.

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