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Updated: Jun 3, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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细胞毒性四酸衍生物是由植物类型III聚基化合成酶产生的

Toshiyuki Wakimoto1, Takahiro Mori, Hiroyuki Morita

  • 1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Tokyo 113-0033, Japan.

Journal of the American Chemical Society
|March 12, 2011
PubMed
概括

研究人员使用植物特异性的沙合成酶 (BAS) 设计了新的四酸衍生物. 一种衍生物显示出中度的抗增殖活性,扩大了这种多功能酶的潜力.

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