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人类A2A腺受体对抗剂结合的结构

Fei Xu1, Huixian Wu, Vsevolod Katritch

  • 1Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|March 12, 2011
PubMed
概括

结合agonist UK-432097 的腺A2A受体的晶体结构揭示了关键的结构变化. 这种激动剂使受体稳定到特定的活性状态,这对于G蛋白结合受体信号传递至关重要.

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