来自活体等离子体膜的信号
Hernán E Grecco1, Malte Schmick, Philippe I H Bastiaens
1Max Planck Institute for Molecular Physiology, Department of Systemic Cell Biology, Otto-Hahn-Str. 11, D-44227 Dortmund, Germany.
Cell
|March 19, 2011
概括
血是动态信号中心,而不是静态屏障. 计算机模拟显示了复杂的空间组织,对细胞通信至关重要.
科学领域:
- 细胞生物学 细胞生物学
- 生物物理学的生物物理.
背景情况:
- 从历史上看,等离子膜被认为是一种静态屏障.
- 新出现的证据凸显了它作为一个动态的信号器官的作用.
- 它将细胞功能与细胞外环境相结合.
研究的目的:
- 审查等离子体膜信号的动态性质.
- 探索信息限制与传播之间的平衡.
- 讨论计算机模拟如何为空间组织提供信息.
主要方法:
- 关于等离子体膜动态的当前文献的综述.
- 对细胞信号的理论模型的分析.
- 使用计算机模拟来预测空间组织.
主要成果:
- 双向信号依赖于信息限制和传播的平衡.
- 动态机制产生了取决于环境的信号响应.
- 计算机模拟为空间组织提供了反直觉的见解.
结论:
- 血膜是一个复杂的,动态的信号平台.
- 了解它的空间组织是解读细胞通信的关键.
- 计算方法为膜功能提供了新的视角.
相关概念视频
01:32Types of Signaling Molecules
In multicellular organisms, many molecules transmit signals between cells to pass information. These signals vary in complexity and include small peptides, nucleotides, steroids, fatty acid derivatives, and dissolved gases such as nitric oxide. Some signaling molecules diffuse through the plasma membrane to act locally between neighboring cells or travel long distances. Others remain attached to the cell surface, transmitting information to other cells only when they make contact. In some...
01:32Types of Signaling Molecules
In multicellular organisms, many molecules transmit signals between cells to pass information. These signals vary in complexity and include small peptides, nucleotides, steroids, fatty acid derivatives, and dissolved gases such as nitric oxide. Some signaling molecules diffuse through the plasma membrane to act locally between neighboring cells or travel long distances. Others remain attached to the cell surface, transmitting information to other cells only when they make contact. In some...
01:23Overview of Cell Signaling
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
01:23Overview of Cell Signaling
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
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02:03What is Cell Signaling?
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
02:03What is Cell Signaling?
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.