细胞决策和生物噪声:从微生物到哺乳动物
Gábor Balázsi1, Alexander van Oudenaarden, James J Collins
1Department of Systems Biology-Unit 950, The University of Texas MD Anderson Cancer Center, 7435 Fannin Street, Houston, TX 77054, USA.
Cell
|March 19, 2011
概括
细胞决策驱动着不同的细胞命运,而没有遗传变化,创造了必要的非遗传多样性. 这一过程受到网络结构和分子噪声的影响,是发展和生存的关键.
科学领域:
- 发展生物学 发展生物学
- 细胞生物学 细胞生物学
- 系统生物学 系统生物学
背景情况:
- 细胞决策产生可遗传的细胞命运,没有遗传或环境差异.
- 这种随机过程创造了非遗传细胞多样性,这对发育和生存至关重要.
- 非遗传多样性有助于微生物资源的利用和适应压力.
研究的目的:
- 审查不同生物体细胞决策的例子.
- 突出监管网络结构和分子噪声的作用.
- 提出细胞决策作为一个基本的发育过程.
主要方法:
- 关于细胞决策的文献综述 举例.
- 监管网络结构的分析.
- 在细胞系统中检查分子噪声.
主要成果:
- 在病毒,细菌,酵母,下层甲基动物和哺乳动物中观察到的细胞决策.
- 调控网络结构和分子噪声显著影响细胞命运.
- 非遗传多样性对于在波动的环境中适应和生存至关重要.
结论:
- 细胞决策是跨生物尺度的广泛现象.
- 它是非遗传多样性的关键驱动力,对生物复杂性至关重要.
- 这个过程被认为是生物发育中的三个核心机制之一.
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