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Updated: Jun 3, 2026

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
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对于S-adenosylmethionine依赖的甲基转移酶,一个完全不同的机制

Tyler L Grove1, Jack S Benner, Matthew I Radle

  • 1Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.

Science (New York, N.Y.)
|March 19, 2011
PubMed
概括

激进的S-adenosylmethionine (SAM) 酶通过独特的乒乓球机制在核糖体RNA上甲基化非核友性位点. 这涉及氨酸残留物的中间甲基化,与典型的S(N) 2甲基转移酶反应不同.

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