探索癌细胞的基因组:进展和承诺
1Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. mrs@sanger.ac.uk
Science (New York, N.Y.)
|March 26, 2011
概括
癌症基因组研究即将完成,揭示了癌症细胞起源和行为的洞察力. 这些基因组数据对于提高癌症诊断和治疗策略至关重要.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 癌症生物学 癌症生物学
背景情况:
- 100多年来,癌细胞中的基因组异常一直是研究的中心焦点.
- 人类瘤基因组的综合测序正在积极进展.
- 该领域准备在许多癌症中生成大量体质突变目录.
研究的目的:
- 提供癌症基因组测序工作当前发现的概述.
- 解释基因组信息如何被用于改善癌症诊断.
- 突出基因组数据在推进癌症治疗中的应用.
主要方法:
- 在不同的人类瘤中对癌症基因组的详尽测序.
- 大规模基因组数据集的分析.
- 解读体质突变及其影响.
主要成果:
- 基因组研究为癌细胞的起源提供了重要的见解.
- 通过基因组分析,对癌细胞行为特征的理解得到了进步.
- 基因组信息正在积极转化为临床应用.
结论:
- 癌症基因组测序计划正在接近其最终目标.
- 未来十年将为成千上万种癌症提供全面的突变目录.
- 基因组洞察力从根本上改善了癌症诊断和治疗策略.
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