在T2*磁共振和心脏铁检测上
John-Paul Carpenter1, Taigang He, Paul Kirk
1Royal Brompton and Harefield NHS Trust, London, SW3 6NP, UK.
Circulation
|March 30, 2011
概括
使用心血管磁共振 (CMR) 精确测量心脏铁是管理侧侧性心肌病的关键. 这项研究为CMR R2*与心肌铁度进行了人体校准,验证了当前的临床实践.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 生物物理学的生物物理.
背景情况:
- 对心肌铁的测量对于治疗侧侧性心肌病症至关重要.
- 心血管磁共振 (CMR) R2* (T2*) 评估心脏铁,但人类校准数据有限.
研究的目的:
- 为了确定CMR R2*与心肌铁度相对应的人类校准方程.
- 为了研究人类心脏内的铁分布.
主要方法:
- 研究了来自输血依赖患者的12颗人类心脏.
- 使用感应合血原子发射光谱法测量心肌铁度.
- 与CMR R2*值相关联的心肌铁度.
主要成果:
- 脊心铁度高于内心铁度.
- 开发了校准方程:[Fe]=45.0×(T2*) −1·22.
- 发现的中腹隔膜铁度和R2*代表了全球心肌铁的平均值.
结论:
- 为CMR R2*提供人体校准到心肌铁度.
- 心脏铁含量过重与心力衰竭和死亡有关.
- 在体内通过中 septum 验证心脏铁的CMR监测.
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