嗅觉皮层的感觉地图是由单个神经元的远程病毒追踪定义的
Sulagna Ghosh1, Stephen D Larson, Hooman Hefzi
1Department of Cell Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, California 92037, USA.
Nature
|April 1, 2011
概括
嗅觉的大脑绘制图显示,虽然嗅觉球泡有一个设置的地图,大脑皮层的个体神经元广泛重新连接. 在中枢神经元和形神经元 (MT) 中,这种个体电线多样性允许复杂的气味处理.
科学领域:
- 神经科学是一个神经科学.
- 嗅觉系统 嗅觉系统
- 感官处理 感官处理
背景情况:
- 感官信息通过轴突输入在大脑中映射出来,这些输入可以是刻板的,也可以是个别变化的.
- 在嗅觉中,嗅球 (OB) 显示了一个刻板的地图,具有空间不变的质体.
- 两神经元和神经元 (MT) 向皮层处理中心中继球信息,但它们的皮层映射不清楚.
研究的目的:
- 为了研究定义的MT神经元集的皮质投影.
- 了解单个MT神经元如何在皮质中映射质信息.
- 探索个体神经电线多样性在嗅觉处理中的作用.
主要方法:
- 使用了新的病毒追踪技术.
- 为了详细分析,采用了三维大脑重建.
- 对比特定的MT神经元群体的皮质投影模式.
主要成果:
- 大规模的OB组织在某些皮质目标中被保留,但在其他目标中被重新排序.
- 个别的MT神经元在皮层投射中不保留球体秩序或刻板印象.
- 来自同一粒球体的同型MT神经元化广泛的,个别变化的区域,具有广泛的轴突分歧和不重叠的分支.
结论:
- 皮层映射策略在嗅觉处理中心之间有所不同.
- 单个MT神经元在皮层中明显重组感官地图,支持扩展组合集成.
- 其他类似的输出神经元的多样化在嗅觉编码中发挥了意想不到的作用.
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