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Updated: Jun 3, 2026

In-vitro Reconstitution of Bacterial Ubiquitination and VCP/p97-mediated Elimination
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线性ubiquitination可以预防炎症,并调节免疫信号

Björn Gerlach1, Stefanie M Cordier, Anna C Schmukle

  • 1Tumour Immunology Unit, Department of Medicine, Imperial College London, W12 0NN London, UK.

Nature
|April 2, 2011
PubMed
概括

SHARPIN被认为是免疫信号中的关键蛋白质. 它通过调节线性ubiquitination in vivo来预防TNF诱导的细胞死亡和炎症.

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