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Nephrotic Syndrome I : Introduction
01:24

Nephrotic Syndrome I : Introduction

Published on: June 19, 2025

476

SHARPIN形成一个线性无素酶复合体,调节NF-κB活性和亡

Fumiyo Ikeda1, Yonathan Lissanu Deribe, Sigrid S Skånland

  • 1Frankfurt Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University School of Medicine, Theodor-Stern-Kai 7, D-60590 Frankfurt, Main, Germany.

Nature
|April 2, 2011
PubMed
概括

SHARPIN蛋白是线性无素链组合复合体 (LUBAC) 的关键组成部分,调节免疫反应. 它的缺失会破坏NF-κB和亡途径,导致小鼠严重的炎症和免疫障碍.

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