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Updated: Mar 31, 2026

Generation of a RIP1 Knockout U937 Cell Line Using the CRISPR-Cas9 System
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通过TNF-α前信号,NEMO和RIP1控制细胞命运,以应对广泛的DNA损伤

Sharon Biton1, Avi Ashkenazi

  • 1Department of Molecular Oncology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

Cell
|April 5, 2011
PubMed
概括

在DNA受损后,阿塔克西亚特朗吉克塔西亚突变 (ATM) 激酶信号会释放细胞因子和亡. 这项研究揭示了一个p53独立的途径,涉及NF-κB和RIP1激酶,对于细胞命运决定至关重要.

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