通过神经信号传递促进前突触,以气味驱动的食物搜索为媒介
Cory M Root1, Kang I Ko, Amir Jafari
1Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Cell
|April 5, 2011
概括
饥饿通过改变嗅觉敏感度来调节Drosophila的寻找食物的行为. 这涉及到在嗅受体神经元 (ORN) 中整合短性神经F (sNPF) 和胰岛素信号,增强强健的食物搜索的气味地图.
科学领域:
- 神经科学是一个神经科学.
- 动物行为 动物行为
- 分子生物学分子生物学
背景情况:
- 内部生理状态显著影响行为决策.
- 了解这些状态如何调节行为的细胞和分子基础至关重要.
研究的目的:
- 为了研究饥饿的基本机制调节在第一个嗅觉突触的Drosophila寻找食物的行为.
- 阐明嗅觉敏感性是如何通过代谢线索调节的.
主要方法:
- 利用双光子成像测量嗅觉受体神经元 (ORN) 中的前突触活性.
- 研究了特定信号通路 (sNPF,胰岛素) 在调节行为中的必要性和充分性.
- 分析了sNPF及其受体 (sNPFR1) 的基因表达水平.
主要成果:
- 饥饿通过短神经F (sNPF) 信号传递增加了特定ORN (Or42b) 中的前突触活性.
- 在Or42b神经元中sNPF受体1 (sNPFR1) 的表达对于饥饿诱导的食物搜索行为至关重要.
- 在Or42b神经元中预突触促进可以模仿被的的饥饿行为.
- 饥饿对sNPFR1转录进行上调,而胰岛素信号抑制它.
结论:
- 饥饿通过在ORN集成sNPF和胰岛素信号来调节嗅觉灵敏度.
- 在饥饿下增加sNPFR1表达改变了气味图,导致增强的食物搜索行为.
- 这项研究揭示了将代谢状态与感官处理和行为联系起来的分子机制.
更多相关视频
10:16Perforated Patch-clamp Recording of Mouse Olfactory Sensory Neurons in Intact Neuroepithelium: Functional Analysis of Neurons Expressing an Identified Odorant Receptor
Published on: July 13, 2015
07:49Electrophysiological Recording from Drosophila Trichoid Sensilla in Response to Odorants of Low Volatility
Published on: July 27, 2017
相关概念视频
Physiology of Smell and Olfactory Pathway
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
Regulation of Food Intake
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
Olfaction
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
Olfactory Receptors: Location and Structure
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
