艾滋病毒感染患者肝病负担增加
Deepak Joshi1, John O'Grady, Doug Dieterich
1Institute of Liver Studies, King's College Hospital, London, UK.
有效的艾滋病毒治疗将艾滋病毒转化为慢性疾病,但会增加由病毒共感染和非酒精性脂肪肝疾病引起的肝病风险. 管理策略对于改善患者治疗结果至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 联合抗逆转录病毒疗法 (cART) 使人体免疫缺陷病毒 (HIV) 感染成为一种慢性可控的疾病.
- 虽然cART降低了与艾滋病相关的死亡率,但由于病毒共感染 (乙型肝炎和C型肝炎),非酒精性脂肪肝病 (NAFLD),药物诱导性肝损伤 (DILI) 和肝细胞癌 (HCC),肝病负担增加了.
研究的目的:
- 提供对艾滋病毒感染个体肝病的主要原因和病变的全面概述.
- 在艾滋病毒管理的背景下,讨论肝病的当前和新兴治疗策略,包括肝移植的作用.
主要方法:
- 文献综述和综合现有关于艾滋病毒和肝脏疾病的研究.
- 对艾滋病毒感染个体肝脏并发症的流行病学数据和临床研究的分析.
主要成果:
- 艾滋病毒与乙型肝炎和型肝炎病毒的同时感染显著导致肝脏发病率和死亡率.
- 非酒精性脂肪肝病和药物诱导的肝毒性越来越多地被认为是艾滋病毒阳性人群中肝病的主要原因.
- 肝细胞癌的发展是一个重大问题,需要积极的查和管理.
结论:
- 针对病毒性肝炎,NAFLD,DILI和HCC的综合管理策略对于减轻HIV感染患者的肝病至关重要.
- 肝移植的作用正在演变,可能为某些因艾滋病毒相关并发症而患有末期肝病的患者提供可行的选择.
更多相关视频
12:24A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
07:21Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment
Published on: June 23, 2019
相关概念视频
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Hepatitis
