酸丁胆的肠道菌群代谢促进心血管疾病
Zeneng Wang1, Elizabeth Klipfell, Brian J Bennett
1Department of Cell Biology, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Nature
|April 9, 2011
概括
代谢学家确定胆,三甲基胺N氧化物 (TMAO) 和贝他因作为预测心血管疾病 (CVD) 风险的血代谢物. 肠道细菌和饮食影响这些代谢物,影响动脉样硬化发展.
科学领域:
- 生物化学 生物化学
- 心血管科学 心血管科学
- 微生物组研究 微生物组研究
背景情况:
- 心血管疾病 (CVD) 是全球主要的死亡原因.
- 代谢学提供了一种有前途的方法来发现与疾病相关的途径.
- 识别CVD风险的新生物标志物对于预防和治疗至关重要.
研究的目的:
- 利用代谢学来无偏见地识别预测心血管疾病风险的血小分子代谢物.
- 调查已识别的代谢物及其代谢途径在动脉样硬化病变发生过程中的作用.
- 探索饮食,肠道微生物群和遗传因素对代谢物产生和心血管疾病风险的影响.
主要方法:
- 进行了血代谢分析,以确定与心血管疾病风险相关的小分子.
- 确定了三个关键代谢物胆,三甲基胺N氧化物 (TMAO) 和贝他因.
- 用小鼠 (包括无细菌模型) 的体内研究来评估这些代谢物对动脉样硬化,巨细胞功能和肠道菌群的作用的影响.
主要成果:
- 在大型临床队列中,胆,TMAO和贝他因被确定为心血管疾病风险的预测因素.
- 胆或TMAO的食补充剂通过上调巨细胞拾尸体受体促进了小鼠的动脉样硬化.
- 肠道微生物群从饮食中的胆中关键调解TMAO的产生,影响胆固醇的积累和泡细胞的形成;肠道菌群的抑制抑制了胆增强的动脉样硬化.
结论:
- 饮食中酸丁胆的新陈代谢,特别是其通过肠道微生物群转化为TMAO,与心血管疾病的发病有关.
- 这些发现揭示了一种新的途径,涉及动脉样硬化中的肠道菌群依赖代谢.
- 已识别的代谢物和途径为动脉样硬化心脏病的新诊断工具和治疗策略提供了潜在的目标.
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