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Updated: Jun 2, 2026

Biotin-based Pulldown Assay to Validate mRNA Targets of Cellular miRNAs
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CPEB和两个多聚A聚合酶控制miR-122的稳定性和p53mRNA的翻译

David M Burns1, Andrea D'Ambrogio, Stephanie Nottrott

  • 1Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

Nature
|April 12, 2011
PubMed
概括

缺陷的生殖线发育2 (Gld2) 枯竭令人惊地增强了p53 mRNA翻译和细胞衰老. 这项研究揭示了一种新的调节途径,涉及Gld2,miR-122,细胞质多化元素结合蛋白 (CPEB) 和Gld4控制衰老.

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