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小分子化合物的可控输送到目标细胞使用碳纳米管

Zhengding Su¹, Shuihan Zhu, Apraku D Donkor

¹Department of Chemistry, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.

Journal of the American Chemical Society

|April 14, 2011

概括

碳纳米管 (CNTs) 将小分子化合物 (SMCs) 输送到目标细胞. 近红外 (NIR) 光触发了这些SMC的受控释放,用于选择性细胞杀死.

科学领域:

纳米技术纳米技术
生物医学工程生物医学工程
材料科学材料科学材料科学

背景情况:

碳纳米管 (CNT) 具有独特的物理化学特性,使其适合生物技术和医学中的分子运输.
在CNT中封装分子提供稳定性,并使创建新型纳米设备成为可能.
CNTs可以作为小分子化合物 (SMC) 的可控制载体.

研究的目的:

证明使用CNT作为可控制的载体来运输和交付SMC到目标细胞.
开发一种使用CNT进行选择性细胞杀死的有针对性的输送系统.
为了研究近红外 (NIR) 触发的封装分子的释放.

主要方法:

印度尔被用作在CNT (indole@CNTs) 中封装的模型SMC.
Indole@CNTs与EphB4结合一起功能化,以创建细胞归根结合物 (CID).
研究了针对性输送和NIR触发的印的释放到表达EphB4的细胞上.

主要成果:

在运输过程中,CNT有效地保护了醇分子.
CIDs选择性地向表达EphB4的细胞.
尼尔射线照射诱导了印的释放,在没有局部过热的情况下显示出显著的细胞杀伤效应.

结论:

对于中小企业来说,CNT是有效的近红外可控制的交付工具.
这个系统可以通过封装化合物实现有针对性的输送和选择性细胞杀死.
开发的纳米载体系统有望用于先进的生物医学应用.

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