Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Deconstructing the black box of zeolite crystallization gels by species-specific isolation.

Chemical science·2026

Same author

Matrine and oxymatrine: a comprehensive review of multitarget mechanisms and therapeutic potential.

Journal of natural medicines·2026

Same author

An acoustic sensing fabric based on PVDF-HFP nanofiber core-shell yarns for respiratory acoustic signal monitoring.

Nanoscale horizons·2026

Same author

PAD4-mediated citrullination of IGF2BP2 stabilizes MCM mRNAs to drive intrahepatic cholangiocarcinoma progression.

Journal of advanced research·2026

Same author

Uncovering the quality markers and mechanisms of Gastrodia elata against LPS-induced neuroinflammation via network pharmacology and experimental verification.

Journal of ethnopharmacology·2026

Same author

ARF6 promotes the nuclear translocation of β-catenin to facilitate AFP deficiency-mediated metastasis in CTNNB1<sup>S33Y</sup>-mutant hepatocellular carcinoma.

Cell biology and toxicology·2026

Same journal

Radical Cascades on Seawater Microdroplets Drive Atmospheric Mercury Oxidation.

Journal of the American Chemical Society·2026

Same journal

Superior Selective and Fast NH<sub>3</sub> Adsorption of Soft Porous MOF/Ionic Liquid Composites with Ordering Phase Transitions.

Journal of the American Chemical Society·2026

Same journal

Systematic Catalyst Variation for Improved Stereoselective Epoxide Polymerization: Subtle Modifications Resulting in Superior Efficiency.

Journal of the American Chemical Society·2026

Same journal

Deciphering the Halide Chemistry of Cl<sup>-</sup> and Br<sup>-</sup> in Enhancing Kinetics of Mg Plating/Stripping.

Journal of the American Chemical Society·2026

Same journal

Electrosynthesis of C<sub>6</sub> Chemicals by Propylene Oxidative Coupling on Au Surface.

Journal of the American Chemical Society·2026

Same journal

Statistical AI Enables Precise Screening of Multielement Catalysts.

Journal of the American Chemical Society·2026

查看所有相关文章

Search research articles

相关实验视频

Updated: Jun 2, 2026

Fabrication of Large-area Free-standing Ultrathin Polymer Films

Fabrication of Large-area Free-standing Ultrathin Polymer Films

Published on: June 3, 2015

细胞表面工程使用聚电解质多层薄膜.

John T Wilson¹, Wanxing Cui, Veronika Kozlovskaya

¹Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.

Journal of the American Chemical Society

|April 16, 2011

概括

此摘要是机器生成的。

研究人员为细胞表面开发了无毒的多层聚电解质 (PEM) 薄膜. 这些工程细胞表面使新疗法和体内输送应用成为可能,克服了以前的细胞毒性挑战.

更多相关视频

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

Fabricating Reactive Surfaces with Brush-like and Crosslinked Films of Azlactone-Functionalized Block Co-Polymers

Fabricating Reactive Surfaces with Brush-like and Crosslinked Films of Azlactone-Functionalized Block Co-Polymers

Published on: June 30, 2018

相关实验视频

Last Updated: Jun 2, 2026

Fabrication of Large-area Free-standing Ultrathin Polymer Films

Fabrication of Large-area Free-standing Ultrathin Polymer Films

Published on: June 3, 2015

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

Fabricating Reactive Surfaces with Brush-like and Crosslinked Films of Azlactone-Functionalized Block Co-Polymers

Fabricating Reactive Surfaces with Brush-like and Crosslinked Films of Azlactone-Functionalized Block Co-Polymers

Published on: June 30, 2018

科学领域:

生物材料科学生物材料科学
细胞工程细胞工程
纳米技术纳米技术

背景情况:

聚电解质多层 (PEM) 薄膜的层层组装提供了对细胞表面修饰的精确控制.
传统的多种细胞的高细胞毒性阻碍了对可活细胞的PEM制造.

研究的目的:

为了设计一种新型的非细胞毒性PEMs类别,用于可行的细胞表面修饰.
开发可调节的PEM,具有模块化生物功能和可控制的物理化学特性.
为了证明PEM工程细胞在体内适用于移植和药物输送.

主要方法:

合理设计的阴离子共聚物经历了构造变化,以减轻细胞膜破坏.
这些工程共聚合物的层次组装到活细胞上.
细胞活力,功能和移植后的体内表现以及作为输送载体的评估.

主要成果:

发现了能够在细胞上进行非细胞毒性PEM沉积的特定阴离子共聚物.
证明可定制的PEM属性,包括组成,反应性,厚度和机械.
在体内成功移植PEM工程细胞,保持活力和功能.
利用PEM工程细胞作为生物分子有效载荷的体内传递载体.

结论:

一个新的生物相容的PEM类别已经被设计出来,克服了以前的细胞毒性限制.
这项技术使得细胞表面的精确,可定制的修改能够用于治疗应用.
开发的设计策略为细胞移植和基于细胞的工程疗法建立了一个平台.