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A GFP Complementation-based Dual-expression System for Assessing Cell-Cell Contact Mediated by Cytonemes in Live Drosophila Wing Imaginal Discs
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对于不同的信号通路而言,Drosophila细胞系的特异性

Sougata Roy1, Frank Hsiung, Thomas B Kornberg

  • 1Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.

Science (New York, N.Y.)
|April 16, 2011
PubMed
概括

细胞可以创建专门的细胞膜,这是细胞扩展,专门接收信号,如Decapentaplegic (Dpp) 和Spitz. 这种有针对性的通信确保了细胞之间准确的形态原体信号传递.

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...