连续的突触激发和抑制形成了为自愿行为准备的释放
Katsushi Kagaya1, Masakazu Takahata
1Department of Biological Sciences, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan. kagaya@sci.hokudai.ac.jp
概括
科学家们发现了鱼大脑活动如何为自愿行动做准备. 准备放电涉及连续的神经细胞激发和抑制,揭示了自我启动行为的机制.
科学领域:
- 神经科学是一个神经科学.
- 动物行为 动物行为
- 突触性可塑性 突触性可塑性
背景情况:
- 在动物中,自愿性行为启动与预备性神经活动有关.
- 这种准备的具体神经元和突触机制尚未完全理解.
研究的目的:
- 研究准备放电在启动自愿行为的神经基础.
- 阐明参与预备神经活动的突触机制.
主要方法:
- 在 (Procambarus clarkii) 的大脑中进行的电生理学记录.
- 在准备放电期间分析神经元发射模式和突触相互作用.
主要成果:
- 准备放电是由连续的突触刺激和抑制形成的.
- 准备放电神经元通过轴突附带来激活局部内部神经元.
- 这个过程似乎发生在大脑内,没有来自下游质的反.
结论:
- 提出了一个模型,即准备放电是由大脑内的连续突触事件形成的.
- 这种神经回路适用于处理信号,以启动自发的自愿行为.
相关概念视频
Synaptic Signaling
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Synaptic Signaling
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Chemical Synapses
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Chemical Synapses
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Excitatory and Inhibitory Effects of Neurotransmitters
When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of specific...
Integration of Synaptic Events
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...


