可注射延长释放的纳尔特雷克松用于阿片类药物依赖:双盲,安慰剂控制,多中心随机试验
Evgeny Krupitsky1, Edward V Nunes, Walter Ling
1Bekhterev Research Psychoneurological Institute, St Petersburg State Pavlov Medical University, St Petersburg, Russia. kruenator@gmail.com
Lancet (London, England)
|May 3, 2011
概括
延长释放纳勒 (XR-NTX) 显著改善了阿片类药物依赖患者的戒断率,并减少了对阿片类药物依赖的渴望. 这种注射治疗为传统的阿片类药物激动剂疗法提供了一个有希望的替代方案.
科学领域:
- 药理学 药理学是指药理学的学科.
- 成 药物 药物 药物 药物
- 临床试验 临床试验
背景情况:
- 阿片类药物依赖是一个重要的公共卫生问题,治疗参与度低,复发率高.
- 目前的治疗方法往往面临着坚持和有效性的挑战.
- 在阿片类药物依赖管理方面,需要新的治疗选择.
研究的目的:
- 评估可注射延长释放纳勒 (XR-NTX) 的疗效,安全性和患者报告的结果.
- 在解毒后对阿片类药物依赖的患者进行XR-NTX评估.
- 在随机对照试验中,将XR-NTX与安慰剂进行比较.
主要方法:
- 这是一项为期24周的双盲,安慰剂控制,随机化试验,涉及俄罗斯250名患者.
- 患者接受了380毫克XR-NTX或安慰剂,以及心理咨询.
- 主要终点是确认戒断;次要终点包括无阿片类药物的日子,渴望,保留和复发率.
主要成果:
- 在XR-NTX组中,确诊的戒断率显著更高 (90.0%对35.0%,p=0.0002).
- 接受XR-NTX治疗的患者报告了更多的无阿片类药物日 (99.2% vs 60.4%,p=0.0004) 和减少渴望 (p<0.0001).
- 在XR-NTX检测中,保留率高 (p=0.0042) 和复发率明显低 (p<0.0001).
结论:
- 注射式XR-NTX是一种有效和安全的治疗选择,用于阿片类药物依赖后排毒.
- XR-NTX为阿片类激动剂维持疗法提供了一个独特的替代方案.
- 结合心理社会支持,XR-NTX可能会提高患者接受治疗和治疗结果.
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