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大分子拥挤不能折叠细胞中的球状蛋白质

Alexander P Schlesinger1, Yaqiang Wang, Xavier Tadeo

  • 1Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

Journal of the American Chemical Society
|May 4, 2011
PubMed
概括

细胞拥挤通过排斥体积稳定蛋白质,但非特异性相互作用可以抵消这种效应. 研究表明大肠杆菌细胞质不能完全稳定蛋白质变体,这表明这些相互作用是显著的.

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