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Updated: Jun 2, 2026

Screening for Amyloid Aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis
10:03

Screening for Amyloid Aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis

Published on: July 16, 2008

在体外进行人类蛋白聚合的多阶段途径:从多重体种子到β-寡合体和非纤维结构

Kang R Cho1, Yu Huang, Shuiliang Yu

  • 1Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California 94550, USA.

Journal of the American Chemical Society
|May 4, 2011
PubMed
概括

研究了异常蛋白质聚合,这是克鲁茨菲尔特-雅各布病 (CJD) 的标志. 研究人员发现,蛋白质聚合物通过较小的β-寡合体的结合而形成,而不是通过添加单个蛋白质.

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Monitoring Cell-to-cell Transmission of Prion-like Protein Aggregates in Drosophila Melanogaster

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Isolation of Soluble and Insoluble PrP Oligomers in the Normal Human Brain11:29

Isolation of Soluble and Insoluble PrP Oligomers in the Normal Human Brain

Published on: October 3, 2012

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

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Protein Complex Assembly

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Protein Folding

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Protein Folding01:22

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Overview