光敏剂药物通过光纤传递
Matibur Zamadar1, Goutam Ghosh, Adaickapillai Mahendran
1Department of Chemistry and Graduate Center, City University of New York, Brooklyn College, Brooklyn, New York 11210, USA.
Journal of the American Chemical Society
|May 5, 2011
概括
一种新的光纤探测器为向治疗提供光敏剂分子和单片氧. 最佳的交付发生在60nmol的fheoforbide下,最大限度地减少了潜在的光动力学治疗应用的自我灭.
科学领域:
- 生物医学工程 生物医学工程
- 摄影化学的使用.
- 材料科学 材料科学 材料科学
背景情况:
- 光动力疗法 (PDT) 是一种使用光敏剂和光来产生细胞毒性单片氧的治疗方式.
- 有效地将光敏剂传递到目标组织,特别是在低氧环境中,仍然是一个挑战.
- 开发有针对性的输送系统对于提高PDT的疗效和最大限度地减少非目标效应至关重要.
研究的目的:
- 开发和描述一种新的光纤迷你探头,用于控制光敏剂分子和单片氧的输送.
- 为了研究从探头尖端对化光敏剂的最佳加载和释放条件.
- 评估该系统在低氧结构的光动力学治疗中的潜力.
主要方法:
- 制造一个可操纵的光纤迷你探头,能够发射氧气.
- 在探头上加载甲基 (光敏感剂) 并使用在位生成的单片氧进行光分离.
- 在不同介质 (石油和二) 中释放光敏剂的量化,以评估传递效率.
主要成果:
- 在60nmol的负载下实现了最佳的光敏化剂 (甲) 光释放,最大限度地减少了分子拥挤和自我灭.
- 光纤探测器成功地将甲基分子和单片氧气传递到离散位置.
- 光敏感剂的释放在石油酸盐中是有效的,但在二中效率较低,在探头上仍然存在显著的吸附.
结论:
- 开发的光纤迷你探头能够有针对性地提供光敏剂和单片氧.
- 该系统对低氧组织的光动力学治疗充满希望,需要精确的细胞毒性控制.
- 在不同的生物环境中进一步优化释放机制是临床翻译的必要条件.
相关概念视频
01:23Ophthalmic Drug Delivery Systems
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
01:22Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...