人类乳头瘤病毒类型和复发性宫
1Department of Pathology, Columbia Presbyterian Medical Center, New York, NY.
JAMA
|March 2, 1990
概括
低温治疗后出现的宫内皮质瘤 (CIN) 通常是由与原始病变不同的人类乳头瘤病毒 (HPV) 类型引起的. 然而,同时发生的CIN往往具有相同的HPV类型.
科学领域:
- 妇科 妇科医生 妇科
- 在瘤学瘤学.
- 病毒学 病毒学
背景情况:
- 宫内皮质瘤 (CIN) 是宫的癌前疾病.
- 人类乳头瘤病毒 (HPV) 是CIN的主要原因.
- 低温疗法是CIN的常见治疗方法,但可能会出现复发.
研究的目的:
- 调查冷治疗后复发的CIN是否与与原始病变相同的HPV类型有关.
- 将复发性CIN中的HPV类型与同时发生的CIN病变中的HPV类型进行比较.
主要方法:
- 在宫组织样本中分析HPVDNA.
- 在冷治疗前后的CIN病变中,HPV类型的比较.
- 在同时发生的CIN病变中,HPV类型的比较.
主要成果:
- 八名患有冷治疗后复发性CIN的妇女在治疗后的病变中与治疗前的病变相比,显示出不同的HPV类型.
- 十二名同时患有CIN的女性主要在病变中显示相同的HPV类型 (11分之12).
结论:
- 结冷治疗后复发的CIN经常与新的HPV感染或不同的HPV类型有关.
- 同时发生的CIN病变更有可能是由相同的HPV类型引起的.
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