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The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli
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总合成的Epicoccin G 的总合成

K C Nicolaou1, Sotirios Totokotsopoulos, Denis Giguère

  • 1Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA. kcn@scripps.edu

Journal of the American Chemical Society
|May 10, 2011
PubMed
概括

研究人员开发了一种高效的方法来合成Epicoccin G和相关化合物. 这种新的策略利用了直接的双向硫化,光氧化和Kornblum-DeLaMare重新排列来进行enantioselective合成.

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