临床症状与传染病的传播之间的关系以及对控制的影响
Bryan Charleston1, Bartlomies M Bankowski, Simon Gubbins
1Institute for Animal Health, Pirbright Laboratory, Ash Road, Woking, Surrey GU24 0NF, UK. bryan.charleston@bbsrc.ac.uk
概括
牛中口病的传播时间比预期的要短. 早期检测和快速干预是关键,这可能会减少对有争议的预防措施的需求.
科学领域:
- 兽医流行病学 兽医流行病学
- 传染病的动态传染病的动态
- 动物健康 动物健康
背景情况:
- 传染病的反应性控制策略取决于病例的检测和隔离.
- 在症状出现之前发生的传播比例显著影响了控制成功.
研究的目的:
- 通过实验确定牛口病 (FMD) 的传染期和前症状传播率.
- 根据新的传输数据,重新评估当前口病控制策略的有效性.
主要方法:
- 在牛群中对口病的实验性传播研究.
- 测量病毒分泌和临床症状,以确定感染期.
- 估计在临床症状出现之前发生的传播的比例.
主要成果:
- 据估计,牛口热的平均感染期为1.7天.
- 动物在临床症状出现后平均0.5天就开始感染.
- 在临床症状出现之前发生的传播的比例不到体液中病毒检测预测的一半.
结论:
- 基于病毒检测的口病传染性的当前估计可能高估了传播潜力.
- 较短的感染期和延迟的传染性开始表明,早期检测和快速干预比以前认为的更为关键.
- 有争议的预防性控制措施可能不必要,重点转移到迅速识别和管理受感染的动物.
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