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Updated: Jun 2, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Published on: February 28, 2017

在骨髓性白血病中,诺奇通路的新瘤抑制功能

Apostolos Klinakis1, Camille Lobry, Omar Abdel-Wahab

  • 1Biomedical Research Foundation, Academy of Athens, Athens, Greece.

Nature
|May 13, 2011
PubMed
概括

痕信号通常调节细胞分化. 这项研究发现,诺奇信号中的失活突变会通过破坏血造干细胞分化,导致慢性骨髓单细胞白血病 (CMML).

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The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
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