在Anopheles gambiae中,天然微生物介导的抗菌性对Plasmodium感染具有折射性
Chris M Cirimotich1, Yuemei Dong, April M Clayton
1W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205-2179, USA.
Science (New York, N.Y.)
|May 14, 2011
概括
来自赞比亚的新发现的Enterobacter细菌可以防止疟疾寄生虫Plasmodium falciparum在蚊子中的发展. 这种细菌产生反应性氧物种,为疟疾控制策略提供了一条新的途径.
科学领域:
- 微生物学 微生物学
- 寄生虫学的寄生虫学
- 载体生物学 载体生物学
背景情况:
- 疟疾寄生虫 (Plasmodium) 的传播依赖于蚊子中肠内成功发展.
- 蚊子的肠道微生物群可以影响Plasmodium感染的建立.
- 了解宿主-微生物相互作用对于控制疟疾至关重要.
研究的目的:
- 为了确定蚊子中抑制Plasmodium falciparum感染的微生物因素.
- 阐明一种特定细菌干扰疟疾寄生虫发展的机制.
主要方法:
- 在赞比亚,从野生蚊子种群中分离和识别细菌.
- 在存在肠杆菌的情况下,对蚊子感染Plasmodium falciparum的表型分析.
- 评估细菌-寄生虫相互作用和反应性氧物种的产生.
主要成果:
- 从赞比亚蚊子中分离出来的一个Enterobacter物种赋予了对Plasmodium falciparum感染的抵抗力.
- 这种细菌会干扰寄生虫在入侵中肠表皮之前的发展.
- 抗Plasmodium效应是由细菌产生的活性氧物种介导的.
- 细菌的有效性取决于小,复制的种群,并且独立于蚊子宿主.
结论:
- 来自自然蚊子种群的肠杆菌细菌具有抗Plasmodium的特性.
- 细菌的活性氧物种是抑制疟疾寄生虫传播的关键机制.
- 这一发现为开发基于微生物组的疟疾控制干预措施开辟了新的可能性.
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