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Updated: Jun 1, 2026

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
11:37

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

固相合成,热变性研究,核酶抵抗,以及细胞吸收 (oligodeoxyribonucleoside) 甲基酸-DNA仿真体

Heera Krishna1, Marvin H Caruthers

  • 1Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, Colorado 80309, USA.

Journal of the American Chemical Society
|May 19, 2011
PubMed
概括

新的甲基酸 (Me-P-BH(3)) oligodeoxynucleotides (ODNs) 显示出高的核酶抵抗性和高效的细胞吸收. 这些修改后的ODN对反意义研究和RNA干扰 (RNAi) 应用具有前景.

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