聚合的立体之间的力量在亚纳米尺度上最小化了耳朵中的摩擦
Andrei S Kozlov1, Johannes Baumgart, Thomas Risler
1Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA.
Nature
|May 24, 2011
概括
耳朵 耳朵 耳朵
科学领域:
- 听觉科学是一种听觉科学.
- 生物物理学的生物物理.
- 机械生物学 机械生物学
背景情况:
- 声音检测依赖于毛细胞立体的运动.
- 头发束中的粘性摩擦挑战了听觉灵敏度和频率选择性.
- 主动放大过程部分解决了这一挑战.
研究的目的:
- 研究流体结构相互作用在减轻头发束内粘性摩擦中的作用.
- 描述声音诱导运动期间立体之间的力量.
- 阐明头发束结构如何优化机械传导.
主要方法:
- 在缩放模型上测量力.
- 有限元素分析和水力动力学力估计.
- 随机模拟和高分辨率的干涉测量测量.
- 分析道门的扭曲产品.
主要成果:
- 紧密的立体的叠加使立体之间的液体不动化,减少阻力.
- 流体结构相互作用抑制了挤压运动,但没有滑动运动.
- 尖端链接和顶部连接器进一步减少阻力并稳定结构.
- 立体之间的相对运动仅限于纳米的几分之一.
结论:
- 头发束的结构特征,包括立体的排列和连接蛋白质,最大限度地减少粘性阻力.
- 流体结构相互作用对于敏感和选择性的听觉机械传导至关重要.
- 控制头发束的物理原理被调整为有效的信号检测.
相关概念视频
Hair Cells
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
The Cochlea
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
Mechanism of Ciliary Motion
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
Mechanism of Ciliary Motion
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
Frictional Force
When a body is in motion, it encounters resistance because the body interacts with its surroundings. This resistance is known as friction, a common yet complex force whose behavior is still not completely understood. Friction opposes relative motion between systems in contact, but also allows us to move. Friction arises in part due to the roughness of surfaces in contact. For one object to move along a surface, it must rise to where the peaks of the surface can skip along the bottom of the...
Equilibrium and Balance
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...


