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Updated: Jun 1, 2026

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
11:09

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

Published on: August 1, 2018

设计,合成和验证针对蛋白质-蛋白质和-受体相互作用的β-转向模拟库

Landon R Whitby1, Yoshio Ando, Vincent Setola

  • 1Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|May 26, 2011
PubMed
概括

研究人员开发了一个新的β-转向模拟库,以准蛋白质-蛋白质相互作用. 这家图书馆发现了具有对 κ-阿片类受体 (KOR) 高 afinity 的强有力的小分子,提供了新的治疗线索.

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Protein-protein Interfaces02:04

Protein-protein Interfaces

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Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
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