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06:56
Influenza Virus Propagation in Embryonated Chicken Eggs
Published on: March 19, 2015
猪流感A病毒的长期演变和传播动态
Dhanasekaran Vijaykrishna1, Gavin J D Smith, Oliver G Pybus
1State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China.
Nature
|May 27, 2011
概括
猪流感A型病毒 (SwIV) 构成经济和公共卫生风险. 香港的系统监测显示,洲际移动驱动了Swiv的多样性和演变,影响了流行病的潜力.
科学领域:
- 兽医病毒学 兽医病毒学
- 流行病学 流行病学
- 分子进化分子进化
背景情况:
- 猪流感A型病毒 (SwIV) 造成巨大的经济损失,并构成公共卫生风险,偶尔会导致像H1N1/2009这样的人类大流行.
- 猪的有限系统监测阻碍了对Swiv的起源,进化和传播动态的理解.
- 现有的数据往往来自机会性样本,缺乏纵向和地理定义的信息.
研究的目的:
- 量化分析香港SIV的流行病学,遗传学和抗原学动态.
- 了解 SwIV 在长时间内的进化轨迹和传播模式.
- 提供关于流感病毒在猪和人类中具有流行病潜力的出现的见解.
主要方法:
- 利用了来自香港12年系统监测的650多个SWIV分离物和800个猪血清的数据集.
- 整合了34年的历史数据,重建了长期的病毒动态.
- 采用了定量流行病学,遗传和抗原分析.
主要成果:
- 发现洲际病毒流动是SWIV重组和血统更换的主要驱动因素.
- 观察到一个高度多样化的SwiV群体,在抗原和遗传上与人类流感病毒不同.
- 抗原漂移的增加与病毒重新分类事件有显著的关联.
结论:
- 斯威夫病毒的进化受到洲际引入的重大影响,导致复杂的重新分类和血统更换.
- 这些发现突出了与人类流感病毒相比,SwiV动态的定量差异.
- 了解这些动态,可以对流感病毒的出现提供关键的见解,这些病毒在猪和人类群体中具有流行病和流行病潜力.
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