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相关概念视频

Viral Structure00:56

Viral Structure

Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...
Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
Nucleic acids02:43

Nucleic acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...

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相关实验视频

Updated: Jun 1, 2026

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation
10:58

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation

Published on: August 21, 2019

多价核酸纳米结构 多价核酸纳米结构.

Joshua I Cutler1, Ke Zhang, Dan Zheng

  • 1Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.

Journal of the American Chemical Society
|June 3, 2011
PubMed
概括
此摘要是机器生成的。

研究人员开发了新的多价核酸纳米结构 (PNANs) 来增强基因调节. 这些自我组装的核酸颗粒表现出高细胞吸收率和核酶抗性,而不需要载体.

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A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

Published on: July 25, 2022

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Last Updated: Jun 1, 2026

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation
10:58

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation

Published on: August 21, 2019

Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
09:12

Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods

Published on: May 11, 2018

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
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A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

Published on: July 25, 2022

科学领域:

  • 生物技术是生物技术.
  • 纳米技术 纳米技术
  • 分子生物学分子生物学

背景情况:

  • 多价寡核酸-纳米粒子结合物表现出增强的细胞吸收,生物活性和核酶耐药性.
  • 这些特性归因于寡核酸在纳米粒子表面的密集包装和定向.

研究的目的:

  • 引入一类新的多价核酸纳米结构 (PNANs),仅由交叉链接的,定向的核酸组成.
  • 为了证明PNANs在细胞吸收和基因调节中的有效性,而无需化聚合物携带者.

主要方法:

  • 交叉链接和定向的核酸纳米结构 (PNANs) 的合成.
  • 细胞吸收效率的评估. 细胞吸收效率的评估.
  • 对基因调节能力的评估.
  • 对结合行为和核酶抗性的分析.

主要成果:

  • PNAN可以实现高细胞吸收和基因调节,而无需化聚合物携带者.
  • 这些纳米结构表现出合作的结合行为.
  • PNANs表现出显著的核酶抵抗性.

结论:

  • PNAN代表了一种新型的自我组装核酸纳米结构.
  • 这些结构提供了一种无载体的方法,用于增强基因调节和寡核酸递送.
  • PNAN具有固有的特性,可以提高稳定性和生物活性.