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Cholinergic antagonists bind to cholinergic receptors and limit the effects of acetylcholine and other cholinergic agonists. Based on the specific cholinergic receptor affinity, these antagonists are classified as muscarinic or nicotinic. Anticholinergics interrupt parasympathetic innervations while sympathetic innervations remain uninterrupted. Muscarinic antagonists are also called 'muscarinic antagonists', 'antimuscarinics', or 'parasympatholytics'. Nicotinic antagonists are called...
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Isomerism in Complexes
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类型基体的基体

Bishwajit Paul1, Glenn L Butterfoss, Mikki G Boswell

  • 1Department of Chemistry, New York University, New York, New York 10003, USA.

Journal of the American Chemical Society
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PubMed
概括
此摘要是机器生成的。

研究人员开发了具有轴性性N-aryl类寡合体,使其具有稳定,可分离的形式. 这一突破为控制折叠机形状和结构提供了一种新的方法.

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科学领域:

  • 有机化学 有机化学
  • 聚合物科学 聚合物科学
  • 化学晶体学 化学晶体学

背景情况:

  • 折叠聚合物是合成聚合物,模仿蛋白质的二次结构.
  • 控制折叠材料的形状稳定性和性对于其应用至关重要.
  • N-aryl 类是折叠分子的一类,具有各种结构动图的潜力.

研究的目的:

  • 为了隔离和描述表现轴性性N-aryl类寡合体.
  • 为了研究围绕立体碳-键的旋转能量障碍.
  • 探索一种新的策略,以诱导折叠分子化合物中的 conformational 排序.

主要方法:

  • 合成N-aryl类单体与正位置换的N-aryl侧链.
  • 计算建模用于研究体.
  • 核磁共振 (NMR) 光谱学.核磁共振 (NMR) 光谱学.
  • 一个X射线晶体学.
  • 高性能液态染色学 (HPLC) 用于分离体.
  • 循环二元化 (CD) 光谱学.循环二元化 (CD) 光谱学.

主要成果:

  • 隔离了采用 chiral 折叠而没有传统的 chiral 中心的 N-aryl 类 oligomers.
  • 鉴定出由于围绕C-N键的有限旋转而表现出轴性性的一种单体.
  • 对旋转存在重要的能量障碍的演示,使稳定的亚特罗皮索默形式的净化成为可能.
  • 使用计算和实验技术的组合进行详细的结构和构造分析.

结论:

  • N-aryl 类寡合物可以实现轴性性,从而形成稳定,可分离的体.
  • 这一发现为控制折叠材料的形状性质提供了一种新方法.
  • 这些发现为设计基于折叠材料的新型材料和催化剂开辟了道路.