民主来源于什么? 多能干细胞研究的新轨迹
Christopher Thomas Scott1, Jennifer B McCormick, Mindy C DeRouen
1Stanford University Center for Biomedical Ethics Program on Stem Cells and Society, Stanford University, Stanford, CA 94305-5417, USA. cscott@stanford.edu
Cell
|June 14, 2011
概括
人类诱导多能干细胞 (hiPSCs) 补充,而不是取代人类胚胎干细胞. 对胚胎干细胞研究的资助禁令可能会对hiPSC的发展产生负面影响.
科学领域:
- 干细胞生物学 干细胞生物学
- 生物医学研究的研究.
背景情况:
- 人类诱导的多能干细胞 (hiPSCs) 代表了再生医学的重大进展.
- 了解hiPSCs和人类胚胎干细胞 (hESCs) 之间的关系对于未来的研究方向至关重要.
研究的目的:
- 分析hiPSC发展对更广泛的干细胞研究领域的影响.
- 在科学文献和研究实践中调查hiPSCs和hESCs之间的关系.
主要方法:
- 对干细胞研究出版物的共同作者网络分析.
- 在干细胞研究中使用细胞系的图书统计分析.
主要成果:
- hiPSCs并没有取代hESCs;它们的功能是补充和相互依存的研究工具.
- hiPSCs的发展扩大了,而不是取代了干细胞研究的途径.
结论:
- 为了科学进步,对hiPSC和hESC的持续研究和资助至关重要.
- 政策决策,例如对hESC研究的资助禁令,可能会对hiPSC技术的进步产生意想不到的负面影响.
相关概念视频
Induced Pluripotent Stem Cells
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Somatic cells are...
Induced Pluripotent Stem Cells
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Stem Cell Culture
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Maintenance of the ES Cell State
The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
Embryonic Stem Cells
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
