甲动物的操作子加速从增长停止状态恢复
Alon Zaslaver1, L Ryan Baugh, Paul W Sternberg
1Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.
Cell
|June 14, 2011
概括
线虫的操作子,是生长基因的集群,通过减少对有限的转录资源的竞争,加速从生长停止中恢复. 这种机制增强了基因表达和生物体的恢复,为metazoan进化提供了洞察力.
科学领域:
- 基因组学就是基因组学.
- 发育生物学 发展生物学
- 进化生物学 进化生物学
背景情况:
- 在 Prokaryotes 中,操作子是众所周知的,但它们在 Metazoans 中的功能仍然不清楚.
- 甲动物的操作子,通常含有生长基因,在从生长停止中恢复时被上调.
研究的目的:
- 为了研究操作子在增长停止后的甲动物恢复中的功能意义.
- 阐明操作子促进加速恢复的机制.
主要方法:
- 对恢复性线虫中的基因表达模式的分析.
- 调查转录资源可用性对基因表达的影响.
- 转录资源竞争和基因表达率的数学建模.
主要成果:
- 操作子和非操作子基因表达是反相关的,这表明对转录资源的竞争.
- 在恢复过程中,转录资源是有限的,动物对进一步的减少敏感.
- 将基因聚合到操作子中可以减少促销者竞争,集中转录资源并加速恢复.
结论:
- 操作子通过在快速生长过渡期间优化转录资源分配,在元动物中提供优势.
- 这种操作介导的机制有助于增长停止后的恢复,并且可能已经演变为支持元动物的快速增长阶段.
- 这些发现在不同的线虫物种和状动物Ciona intestinalis中得到保存,这表明了更广泛的进化作用.
相关概念视频
Operons
Prokaryotes can control gene expression through operons—DNA sequences consisting of regulatory elements and clustered, functionally related protein-coding genes. Operons use a single promoter sequence to initiate transcription of a gene cluster (i.e., a group of structural genes) into a single mRNA molecule. The terminator sequence ends transcription. An operator sequence, located between the promoter and structural genes, prohibits the operon’s transcriptional activity if bound by a repressor...
Operons
Prokaryotes can control gene expression through operons—DNA sequences consisting of regulatory elements and clustered, functionally related protein-coding genes. Operons use a single promoter sequence to initiate transcription of a gene cluster (i.e., a group of structural genes) into a single mRNA molecule. The terminator sequence ends transcription. An operator sequence, located between the promoter and structural genes, prohibits the operon’s transcriptional activity if bound by a repressor...
Operon Model
The operon model represents a fundamental mechanism of gene regulation in prokaryotes, enabling coordinated expression of genes involved in related metabolic or functional pathways. Operons consist of structural genes, a promoter, and an operator, with transcription regulated by repressors, activators, and small effector molecules.Structure and Function of OperonsAn operon is a cluster of structural genes transcribed together under the control of a single promoter. The promoter region...
Inducible Operons: lac Operon
The lac operon in Escherichia coli is a model for understanding inducible gene regulation and metabolic flexibility. It integrates local control by lactose and global regulation through catabolite repression, enabling E. coli to preferentially metabolize glucose when available and switch to lactose utilization when glucose is scarce.Structure and Function of the lac OperonThe lac operon contains three structural genes: lacZ (β-galactosidase), lacY (lactose permease), and lacA (thiogalactoside...
Repressible Operon: trp Operon
The trp operon in Escherichia coli exemplifies a repressible operon. It regulates the synthesis of tryptophan through repressor-mediated transcriptional control and attenuation. This dual regulatory mechanism ensures tryptophan biosynthesis occurs only when needed, conserving cellular resources.Structure of the trp OperonThe trp operon consists of five structural genes (trpE, trpD, trpC, trpB, and trpA) that encode enzymes for tryptophan biosynthesis. These genes are transcribed as a single...
Stringent Response in E. coli
Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...


