吸烟和前列腺癌的生存率和复发率
Stacey A Kenfield1, Meir J Stampfer, June M Chan
1Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. skenfiel@hsph.harvard.edu
JAMA
|June 23, 2011
概括
在诊断时吸烟会增加前列腺癌死亡率和复发风险. 戒烟10年或更长时间显著降低前列腺癌死亡风险,类似于从未吸烟的人.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 关于吸烟对前列腺癌死亡率和复发的影响的研究有限.
- 很少有研究集中在与吸烟有关的前列腺癌特定结果上.
研究的目的:
- 评估吸烟和戒烟与前列腺癌患者的死亡率 (整体,前列腺癌特异性,心血管疾病) 和生化复发之间的关联.
主要方法:
- 一项前性观察性研究,涉及5366名被诊断患有前列腺癌的男性 (1986-2006).
- 对死亡率和生化复发 (以PSA水平定义) 计算了危险比率 (HR).
主要成果:
- 与从未吸烟者相比,目前吸烟者面临更高的前列腺癌死亡率 (HR 1.61),生化复发 (HR 1.61),总死亡率 (HR 2.28) 和心血管疾病死亡率 (HR 2.13) 的风险.
- 吸烟40+包年显著增加前列腺癌死亡风险 (HR 1.82).
- 戒烟10多年后,前列腺癌死亡风险降低到与从未吸烟的人相似的水平 (HR 0.60).
结论:
- 诊断时吸烟与前列腺癌患者的死亡率增加和复发有关.
- 戒烟至少10年可减轻前列腺癌特异性死亡风险,使其达到与从未吸烟者相比的水平.
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