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Updated: May 31, 2026

Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains
09:27

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Published on: January 5, 2016

氏病的葡萄糖大脑化酶和α-synuclein在synucleinopathies中形成一个双向的致病循环

Joseph R Mazzulli1, You-Hai Xu, Ying Sun

  • 1Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02129, USA.

Cell
|June 25, 2011
PubMed
概括

帕金森病通过葡萄糖大脑酶 (GCase) 与戈舍病有关. 失去GCase功能会损害蛋白质分解,导致α-synuclein积累和神经毒性,这表明一种共同的疾病机制.

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