立体中心对氨酸基聚合物的自我分类,脱聚合和聚聚合动态的影响
Floris Helmich1, Maarten M J Smulders, Cameron C Lee
1Institute for Complex Molecular Systems, Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
Journal of the American Chemical Society
|July 1, 2011
概括
基拉性氨酸可以在超分子组合中放大基拉性,但混合酶体会导致自我排序. 性放大取决于单体结构和混合策略,影响性记忆效应.
科学领域:
- 超分子化学 超分子化学
- 奇拉性研究 奇拉性研究
- 材料科学 材料科学 材料科学
背景情况:
- 了解超分子组合中的性放大对于开发新的性材料至关重要.
- 单体之间的结构不匹配对自我组装和奇拉性转移的影响尚未完全理解.
研究的目的:
- 调查结构 (错误) 匹配在氨酸单体混合在超分子组件中的作用.
- 探索使用不同的混合策略,如"中士和士兵"和多数规则实验等奇拉放大现象.
- 分析性记忆效应及其对单体组成和混合动力学的依赖.
主要方法:
- 使用氨酸单体的状放大实验.
- 大多数规则和稀释多数规则实验研究反体混合.
- 计算建模以确定不匹配处罚.
- 混合金属实验与铜和-氨酸.
- 光测量和选择性提取使用昆利丁.
主要成果:
- 在螺旋集群中,状酸盐"中士"有效地偏向了状"士兵",证明了状放大.
- 纳西斯主义者自我分类的反体阻止了在多数规则实验中的放大.
- 用阿奇拉尔士兵进行稀释多数规则实验,可以实现反体混合和放大.
- 混合金属系统显示出不同的混合行为,由光和提取动力学证实.
- 观察到一种性记忆效应,不同的混合状态具有不同的动力学和驱动力 (与).
结论:
- 结构不匹配对超分子组合中的单体混合和奇拉放大有显著影响.
- "中士和士兵"和稀释多数规则的方法对于受控的性放大是有效的.
- 状记忆效应与超分子结构和单体组成有关,对信息存储有影响.
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