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Updated: May 31, 2026

Improving Small RNA-seq: Less Bias and Better Detection of 2'-O-Methyl RNAs
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对siRNA非种子区域的干扰微调了沉默能力

Hanna K Hedman1, Finn Kirpekar, Sofi K C Elmroth

  • 1Department of Biochemistry and Structural Biology, Center for Molecular Protein Science, Lund University, P.O. Box 124, SE-22100 Lund, Sweden.

Journal of the American Chemical Society
|July 5, 2011
PubMed
概括

抗癌药物西斯和氧沙被用于化小干扰RNA (siRNAs). 化改变了siRNA降解,但保留了生物活性,尽管它通常降低了沉默能力,而氧化具有更大的效果.

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