相关实验视频
随着时间的推移,癌症家族史中的临床相关变化
Argyrios Ziogas1, Nora K Horick, Anita Y Kinney
1University of California–Irvine, USA.
JAMA
|July 14, 2011
概括
家庭癌症史在30至50岁之间发生显著变化,影响查建议. 这些转变对于个性化癌症风险评估和早期检测策略至关重要.
科学领域:
- 遗传学和流行病学
- 癌症预防和查 癌症预防和查
- 公共卫生研究 公共卫生研究
背景情况:
- 家庭癌症史对于评估个体癌症风险至关重要.
- 它指导了早期检测的个性化查建议.
研究的目的:
- 确定成年期癌症家族病史中临床显著变化的频率.
- 评估这些变化如何影响早期或更密集的癌症查建议.
主要方法:
- 一项描述性研究分析了来自癌症遗传学网络 (CGN) 注册表 (1999-2009) 的家族史数据.
- 追溯和前性分析检查了从出生到入学和从入学到随访的家族史的变化.
- 具体分析的重点是结直肠,乳腺和前列腺癌查标准.
主要成果:
- 追溯分析显示,与30岁相比,50岁的高风险查标准增加了结直肠和乳腺癌.
- 前性分析表明,在20年内,每100人中有2-8人新满足结直肠,乳腺和前列腺癌高风险查标准.
- 结直肠和乳腺癌家族病史的变化率在回顾性和前性分析之间是一致的.
结论:
- 具有临床意义的癌症家族史,促使早期或强烈的查,在30至50岁之间增加结直肠,乳腺和前列腺癌.
- 虽然增加值得注意,但前列腺癌的绝对发病率仍然很低.
- 定期对家族癌症病史进行重新评估对于整个成年期更新查指南至关重要.
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