卡特科尔聚合物用于对pH反应的向药物输送到癌细胞
Jing Su1, Feng Chen, Vincent L Cryns
1Biomedical Engineering Department, Northwestern University, Evanston, Illinois 60208, USA.
Journal of the American Chemical Society
|July 15, 2011
概括
这项研究引入了一种智能聚合物载体,用于向向癌细胞输送博特佐米布 (BTZ). 对pH值敏感的设计增强了药物吸收和对乳腺癌细胞的有效性.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 开发有针对性的药物输送系统对于提高癌症治疗疗效和减少副作用至关重要.
- 博特佐米布 (BTZ) 是一种有效的蛋白酶体抑制剂,用于癌症治疗,但其传递可能具有挑战性.
- 聚合物载体为药物结合和受控释放提供了一个多功能平台.
研究的目的:
- 开发和评估一种新的细胞向,pH敏感的聚合物载体,用于博尔特佐米布 (BTZ) 输送.
- 研究BTZ载荷聚合物合物的向吸收和增强的细胞毒性在癌细胞中.
- 为了建立一个pH值敏感的甲基甲醇酸盐结合机制,以控制药物释放.
主要方法:
- 博特佐米布 (BTZ) 与含有甲基醇的聚乙烯甘醇 (PEG) 载体的结合.
- 纳入生物素作为细胞向连接体,用于受体介导的内细胞分裂.
- 在乳腺癌细胞中评估细胞吸收,蛋白质酶抑制和细胞毒性.
- 评估从catechol-boronate链接中依赖pH的药物释放.
主要成果:
- 新型聚合物载体通过生物介导机制被癌细胞选择性吸收.
- 与非向合物相比,BTZ载荷的聚合物合物显著增强了细胞吸收和蛋白酶体抑制.
- 向的结合物对乳腺癌细胞表现出优越的细胞毒性.
- 敏感于pH的甲基乙醇-酸盐结合促进了BTZ在酸性瘤微环境中的受控释放.
结论:
- 一种新的,pH敏感的,针对细胞的聚合物载体系统有效地将博雷佐米布传递给癌细胞.
- 这一策略通过有针对性的输送和受控释放来提高药物的疗效,为乳腺癌治疗提供了一种有前途的方法.
- 开发的甲基醇-酸盐结合机制可以扩展到其他含酸的治疗药物,用于治疗各种疾病.
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