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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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多域形态选择是U2AF的mRNA前拼接调节的基础

Cameron D Mackereth1, Tobias Madl, Sophie Bonnal

  • 1Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.

Nature
|July 15, 2011
PubMed
概括

人类U2辅助因子65 (U2AF65) 蛋白质使用两种不同的构造来结合RNA,作为分子静止剂. 这种形状选择机制通过控制U2 snRNP招募来调节mRNA前拼接效率.

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