在脊髓损伤后,呼吸道的功能再生
Warren J Alilain1, Kevin P Horn, Hongmei Hu
1Department of Neurosciences, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, Ohio 44106, USA. wja4@case.edu
Nature
|July 15, 2011
概括
用Chondroitinase ABC (ChABC) 治疗脊髓损伤可以促进神经再生并恢复隔膜功能. 将ChABC与神经移植结合起来,可显著增强部脊髓损伤后的呼吸恢复.
科学领域:
- 神经科学是一个神经科学.
- 再生医学是一种再生医学.
- 脊髓损伤研究 脊髓损伤研究
背景情况:
- 脊髓损伤,特别是宫损伤,往往会损害隔膜内置,导致呼吸衰竭和高死亡率.
- 丁硫酸盐蛋白质糖 (CSPGs) 抑制神经可塑性和受伤后的再生.
- 恢复呼吸功能对于改善脊髓损伤患者的治疗结果至关重要.
研究的目的:
- 调查ABC冠状腺酶 (ChABC) 在椎脊髓损伤后恢复隔膜功能方面的治疗潜力.
- 评估ChABC治疗和外围神经自移植对神经再生和功能恢复的综合影响.
主要方法:
- 动物的椎脊髓损伤模型.
- 氏丁酶ABC (ChABC) 酶处理以消化CSPGs.
- 外围神经自移植以弥合受伤部位.
- 评估轴突再生 (血清和球脊纤维).
- 电肌图 (EMG) 用于测量隔膜活动和功能恢复.
主要成果:
- 单独使用ChABC治疗可以通过促进节省的神经通道的可塑性来部分恢复隔膜活动.
- 结合ChABC治疗和神经自移植导致了球脊轴突的广泛再生和隔膜功能的显著恢复.
- 移植的复原后切割取消了恢复的隔膜活动,强调了持续再生的必要性.
结论:
- 冠状腺酶ABC (ChABC) 治疗,特别是与外围神经自移植相结合时,是严重脊髓损伤后恢复隔膜功能的一个有希望的策略.
- 这种方法促进了神经可塑性和再生,提供了功能恢复的双重机制.
- 这些发现强调了持续再生在实现中枢神经系统创伤后的长期功能恢复方面的关键作用.
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