将环境与奖励联系起来:从海马CA3到腹膜区域的功能电路
Alice H Luo1, Pouya Tahsili-Fahadan, Roy A Wise
1Behavioral Neuroscience Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA. alice_luo@hotmail.com
一个新发现的从海马到腹膜区域 (VTA) 的神经通路有助于解释环境环境如何影响寻求奖励的行为. 这种电路对于线索和奖励之间的学会关联至关重要.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 神经生物学 神经生物学 神经生物学
背景情况:
- 环境线索的学习意义对奖励动机行为有深远的影响.
- 背景奖励关联背后的特定神经回路在很大程度上仍未被阐明.
研究的目的:
- 识别和描述介导环境背景对奖励相关行为影响的神经通路.
- 研究海马 - 腹膜积分区域 (VTA) 电路在调节基于上下文线索的目标导向行为中的作用.
主要方法:
- 在海马区域CA3刺激后,VTA中的电生理记录.
- 在体内,特定路径组件 (CA3-侧隔膜-VTA) 的非激活.
- 评估可卡因寻找行为恢复的评估,由上下文刺激介导.
主要成果:
- 刺激海马CA3兴奋多巴胺 (DA) 神经元和抑制VTA中的非DA神经元,这表明一种消毒机制.
- CA3-侧隔膜 (LS) -VTA通路的失活取消了引起的VTA反应,并阻止了因上下文提示而引起的可卡因寻找行为的恢复.
- 确定了从背部海马体 (CA3) 到VTA的直接跨突触电路,通过LS进行中继.
结论:
- 已识别的CA3-LS-VTA通路是一个关键的神经基质,通过它环境环境调节奖励动机和目标导向的行为.
- 这一途径表明,海马体处理的上下文信息如何调节VTA中的多巴胺神经元活动.
- 了解这种电路可以了解成和动机行为的神经生物学基础.
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